Journal Club April 2023
“Effect of Selective Lesions of Nucleus Accumbens µ-Opioid Receptor-Expressing Cells on Heroin Self-Administration in Male and Female Rats: A Study with Novel Oprm1-Cre Knock-in Rats”
Presented By Sarah Masud and Joanna Dearman
Journal Club April 2023
“Nucleus Tractus Solitarius Neurons Activated by Hypercapnia and Hypoxia Lack Mu Opioid Receptor Expression”
Presented By Mubariz Tahirkheli and Talal Abdel Aal
Journal Club March 2023
“Systemic kappa opioid receptor antagonism accelerates reinforcement learning via augmentation of novelty processing in male mice”
Presented By Hasan Maqbool and Basma Daham
Journal Club March 2023
“Mechanisms That Underlie Expression of Estradiol-Induced Excitatory Synaptic Potentiation in the Hippocampus Differ between Males and Females”
Presented By Rachel Teich and Ashley Park
Journal Club March 2023
“Kappa opioid receptor and dynorphin signaling in the central amygdala regulates alcohol intake”
Presented By Haziq Latif-Jangda and Alex Liu
Journal Club March 2023
“Coordinated activity of a central pathway drives associative opioid analgesic tolerance”
Presented By Sulan Pathiranage and Youssef Saad
Journal Club February 2023
“Sex-specific role of the circadian transcription factor NPAS2 in opioid tolerance, withdrawal and analgesia”
Presented By Julian Abt and Bilal Zahoor
Journal Club October 2021
“Cooperative synaptic and intrinsic plasticity in a disynaptic limbic circuit drive stress-induced anhedonia and passive coping in mice”
Presented By Olayinka Idowu
Journal Club July 2021
“Hypoactive Thalamic Crh+ Cells in a Female Mouse Model of Alcohol Drinking After Social Trauma”
Presented by Krishna Vaidyanathan
Journal Club July 2021
“Activation of the dorsal, but not the ventral, hippocampus relieves neuropathic pain in rodents”
Presented by Sulan Pathiranage
Journal Club June 2021
“The rostromedial tegmental nucleus: a key modulator of pain and opioid analgesia”
Presented by Julian Abt
Journal Club June 2021
“Remifentanil self-administration in mice promotes sex-specific prefrontal cortex dysfunction underlying deficits in cognitive flexibility”
Presented by Hannah Frye, PhD
Journal Club May 2021
“Estrogen Receptor α Regulates Ethanol Excitation of Ventral Tegmental Area Neurons and Binge Drinking in Female Mice”
Presented by Yolanda Campos-Jurado, PhD
Journal Club May 2021
“Chronic Stress Induces Activity, Synaptic, and Transcriptional Remodeling of the Lateral Habenula Associated with Deficits in Motivated Behaviors”
Presented by Tamara Markovic, PhD Student
Journal Club March 2021
“Distinct Accumbens Shell Output Pathways Promote versus Prevent Relapse to Alcohol Seeking”
Presented by Nicolas Massaly, PhD
Journal Club March 2021
“Periaqueductal gray/dorsal raphe dopamine neurons contribute to sex differences in pain-related behaviors” by Waylin Yu, Dipanwita Pati, Melanie M. Pina, Karl T. Schmidt, Kristen M. Boyt, Avery C. Hunker, Larry S. Zweifel, Zoe A. McElligott, Thomas L. Kash
Presented by Dominika Burek, PhD Student
Joint Journal Club March 2021
“Lack of effect of different pain-related manipulations on opioid self-administration, reinstatement of opioid seeking, and opioid choice in rats” by David J Reiner, E Andrew Townsend, Javier Orihuel Menendez, Sarah V Applebey, Sarah M Claypool, Matthew L Banks, Yavin Shaham, S Stevens Negus
Presented by David J Reiner, Negus Lab
Journal Club March 2021
“Nucleus accumbens medium spiny neurons subtypes signal both reward and aversion” by Carina Soares-Cunha, Nivaldo A. P. de Vasconcelos, Bárbara Coimbra, Ana Verónica Domingues, Joana M. Silva, Eduardo Loureiro-Campos, Rita Gaspar, Ioannis Sotiropoulos, Nuno Sousa, Ana João Rodrigues
Presented by Tamara Markovic, PhD Student
Journal Club February 2021
“Complete Freud’s adjuvant-induced hyperalgesia: a human perception” by Harry J. Gould III
Presented by Jessica Higginbotham, PhD
Journal Club December 2020
“Energy Reallocation to Breeding Performance through Improved Nest Building in Laboratory Mice” by Brianna N. Gaskill, Kathleen R. Pritchett Corning, Christopher J. Gordon, Edmond A. Pajor, Jeffery R. Lucas, Jerry K. Davis, Joseph P. Garner
Presented by Justin Meyer
Journal Club November 2020
“Dissecting the Role of GABA Neurons in the VTA versus SNr in Opioid Reward” by Ewa Galaj, Xiao Han, Chloe J. Jordan, Yi He, Bree Humburg, Guo-Hua Bi, and Zheng-Xiong Xi
Presented by Tamara Markovic, PhD Student
Journal Club November 2020
“GABA and glutamate neurons in the VTA regulate sleep and wakefulness” by Xiao Yu, Wen Li, Ying Ma, Kyoko Tossell, Julia J. Harris, Edward C. Harding, Wei Ba, Guilia Miracca, Dan Wang, Long Li, Juan Guo, Ming Chen, Yiqi Li, Raquel Yustos, Alexei L. Vyssotski, Denis Burdakov, Qianzi Yang, Hallong Dong, Nicholas P. Franks, and William Wisden
Presented by Nicolas Massaly, PhD
Journal Club October 2020
“Adaptive alterations in the mesoaccumbal network after peripheral nerve injury” by Wenjie Ren, Maria Virginia Centeno, Xuhong Wei, Ian Wickersham, Marco Martina, A Vania Apkarian, D James Surmeier
Presented by Dominika Burek, PhD Student
Journal Club October 2020
“Intermittent hypercapnic hypoxia induces respiratory hypersensitivity to fentanyl accompanied by tonic respiratory depression by endogenous opioids” by Brackley AD, Andrade MA, Toney GM.
Presented by Brian Ruyle, PhD
Journal Club September 2020
“Dorsal and Ventral Hippocampal Sharp-Wave Ripples Activate Distinct Nucleus Accumbens Networks” by Marielena Sosa, Hannah R. Joo, Loren M.Frank
Presented by Khairunisa Ibrahim, PhD
Journal Club September 2020
“Chronic Pain Impairs Memory Formation via Disruption of Neurogenesis Mediated by Mesohippocampal Brain-Derived Neurotrophic Factor Signaling” by Sun-Hui Xia, Su-Wan Hu, De-Gao Ge, Di Liu, Di Wang, Song Zhang, Qi Zhang, Ling Yuan, Yan-Qiang Li, Jun-Xia Yang, Peng Wu, Hongxing Zhang, Ming-Hu Han, Hai-Lei Ding, Jun-Li Cao
Presented by Hannah Frye, PhD Student
Journal Club September 2020
“VTA Glutamate Neuron Activity Drives Positive Reinforcement Absent Dopamine Co-release” by Vivien Zell, Thomas Steinkellner, Nick G. Hollon, Shelley M. Warlow, Elizabeth Souter, Lauren Faget, Avery C. Hunker, Xin Jin, Larry S. Zweifel, Thomas S. Hnasko
Presented by Jessica Higginbotham, PhD
Journal Club September 2020
“Standard laboratory housing for mice restricts their ability to segregate space into clean and dirty areas” by I. Joanna Makowska, Becca Franks, Cathy El-Hinn, Tina Jorgensen & Daniel M. Weary
Presented by Justin Meyer
Journal Club August 2020
“A quantitative reward prediction error signal in the ventral pallidum” by Ottenheimer, D.J., Bari, B.A., Sutlief, E. et al.
Presented by Tamara Markovic, PhD Student
Journal Club August 2020
“Incerta-thalamic Circuit Controls Nocifensive Behavior via Cannabinoid Type 1 Receptors” by Hao Wang, Ping Dong, Chao He, Xiao-Yang Feng, Yue Huang, Wei-Wei Yang, Hua-Jing Gao, Xiao-Fan Shen, Shan Lin, Shu-Xia Cao, Hong Lian, Jiadong Chen, Min Yan, Xiao-Ming Li
Presented by Nicolas Massaly, PhD
Journal Club August 2020
“Basolateral Amygdala Drives a GPCR-Mediated Striatal Memory Necessary for Predictive Learning to Influence Choice” by Ashleigh K. Morse, Beatrice K. Leung, Emily Heath, Jesus Bertran-Gonzalez, Elise Pepin, Billy C. Chieng, Bernard W. Balleine, Vincent Laurent
Presented by Dominika Burek, PhD Student
Journal Club July 2020
“Opioids depress breathing through two small brainstem sites” by Iris Bachmutsky, Xin Paul Wei, Eszter Kish, Kevin Yackle
Presented by Brian Ruyle, PhD
Journal Club July 2020
“Supramammillary neurons projecting to the septum regulate dopamine and motivation for environmental interaction” by Andrew J. Kesner, Rick Shin, Coleman B. Calva, Reuben F. Don, Sue Junn, Christian T. Potter, Leslie A. Ramsey, Ahmed F. Abou-Elnaga, Christopher G. Cover, Dong V. Wang, Hanbing Lu, Yihong Yang, Satoshi Ikemoto
Presented by Khairunisa Ibrahim, PhD
Journal Club July 2020
“SEQUIN Multiscale Imaging of Mammalian Central Synapses Reveals Loss of Synaptic Connectivity Resulting from Diffuse Traumatic Brain Injury” by Sauerbeck AD, Gangolli M, Reitz SJ, Salyards MH, Kim SH, Hemingway C, Gratuze M, Makkapati T, Kerschensteiner M, Holtzman DM, Brody DL, Kummer TT.
Presented by Hannah Frye, PhD Student
Journal Club June 2020
“Anatomic resolution of neurotransmitter-specific projections to the VTA reveals diversity of GABAergic inputs” by Soden, M.E., Chung, A.S., Cuevas, B. et al.
Presented by Jessica Higginbotham, PhD
Journal Club June 2020
“Effect of three different forms of handling on the variation of aggression-associated parameters in individually and group-housed male C57BL/6NCrl mice” by Sinja Mertens, Miriam A. Vogt, Peter Gass, Rupert Palme, Bernhard Hiebl, Sabine Chourbaji
Presented by Justin Meyer
Journal Club June 2020
“The central amygdala recruits mesocorticolimbic circuitry for pursuit of reward or pain” by Warlow, S.M., Naffziger, E.E. & Berridge, K.C.
Presented by Tamara Markovic, PhD Student
Journal Club June 2020
“Orexin signaling in GABAergic lateral habenula neurons modulates aggressive behavior in male mice” by Flanigan, M.E., Aleyasin, H., Li, L. et al.
Presented by Nicolas Massaly, PhD
Journal Club June 2020
“Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking” by Ashley E. Lepack, Craig T. Werner, Andrew F. Stewart, Sasha L. Fulton, Ping Zhong, Lorna A. Farrelly, Alexander C. W. Smith, Aarthi Ramakrishnan, Yang Lyu, Ryan M. Bastle, Jennifer A. Martin, Swarup Mitra, Richard M. O’connor, Zi-jun Wang, Henrik Molina, Gustavo Turecki, Li Shen, Zhen Yan, Erin S. Calipari, David M. Dietz, Paul J. Kenny, Ian Maze
Presented by Dominika Burek, PhD student
Journal Club May 2020
“The Role of peripheral opioid Receptors in triggering Heroin-induced Brain Hypoxia” by Perekopskiy, D., Afzal, A., Jackson, S.N. et al.
Presented by Brian Ruyle, PhD
Journal Club May 2020
“Excitatory VTA to DH projections provide a valence signal to memory circuits” by Han, Y., Zhang, Y., Kim, H. et al.
Presented by Khairunisa Ibrahim, PhD
Journal Club May 2020
“Dopaminergic dynamics underlying sex-specific cocaine reward” by Calipari, E., Juarez, B., Morel, C. et al.
Presented by Hannah Frye, PhD Student
Journal Club May 2020
“Interruption of continuous opioid exposure exacerbatesdrug-evoked adaptations in the mesolimbic dopamine system” by Lefevre, E.M., Pisansky, M.T., Toddes, C. et al.
Presented by Jessica Higginbotham, PhD
Journal Club April 2020
“Nesting material enrichment reduces severity of overgrooming-related self-injury in individually housed rats” by Khoo SY, Correia V, Uhrig A.
Presented by Justin Meyer
Journal Club April 2020
“Periaqueductal Gray and Rostromedial Tegmental Inhibitory Afferents to VTA Have Distinct Synaptic Plasticity and Opiate Sensitivity” by Robyn St. Laurent, Valentina Martinez Damont, Ayumi C.Tsuda, Julie A.Kauer
Presented by Tamara Markovic, PhD Student
Journal Club April 2020
“Facial expressions of emotion states and their neuronal correlates in mice” by Nejc Dolensek, Daniel A. Gehrlach, Alexandra S. Klein, Nadine Gogolla
Presented by Nicolas Massaly, PhD
Journal Club April 2020
“Brain-wide Electrical Spatiotemporal Dynamics Encode Depression Vulnerability” by Hultman R, Ulrich K, Sachs BD, Blount C, Carlson DE, Ndubuizu N, Bagot RC, Parise EM, Vu MT, Gallagher NM, Wang J, Silva AJ, Deisseroth K, Mague SD, Caron MG, Nestler EJ, Carin L, Dzirasa K.
Presented by Dominika Burek, PhD student
Journal Club May
“Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3.” by Lorna A. Farrelly, Robert E. Thompson, Shuai Zhao, Ashley E. Lepack, Yang Lyu, Natarajan V. Bhanu, Baichao Zhang, Yong-Hwee E. Loh, Aarthi Ramakrishnan, Krishna C. Vadodaria, Kelly J. Heard, Galina Erikson, Tomoyoshi Nakadai, Ryan M. Bastle, Bradley J. Lukasak, Henry Zebroski III, Natalia Alenina, Michael Bader, Olivier Berton, Robert G. Roeder, Henrik Molina, Fred H. Gage, Li Shen, Benjamin A. Garcia, Haitao Li, Tom W. Muir and Ian Maze
Presented by Dominika Burek, PhD student
Journal Club April
“A Role of Drd2 Hippocampal Neurons in Context-Dependent Food Intake.” by Estefania P. Azevedo, Lisa Pomeranz, Jia Cheng, Marc Schneeberger, Roger Vaughan, Sarah A. Stern, Bowen Tan, Katherine Doerig, Paul Greengard and Jeffrey M. Friedman
Presented by Tamara Markovic, PhD student
Journal Club February
The Moron Concepcion Lab discusses the paper “Rostral and Caudal Ventral Tegmental Area GABAergic Inputs to Different Dorsal Raphe Neurons Participate in Opioid Dependence.” by Yue Li, Chun-Yue Li, Wang Xi, Sen Jin, Zuo-Hang Wu, Ping Jiang, Ping Dong, Xiao-Bin He, Fu-Qiang Xu, Shumin Duan, Yu-Dong Zhou and Xiao-Ming Li
Presented by Dominika Burek, PhD student
Journal Club January
“Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors.” by Tommaso Patriarchi, et al.
“Stochastic synaptic plasticity underlying compulsion in a model of addiction.” by Vincent Pascoli, et al.
Presented by – Nicolas Massaly, Instructor
Journal Club: November Paper
The Moron Concepcion Lab discusses the paper “Maladaptive behavioral regulation in alcohol dependence: Role of kappa-opioid receptors in the bed nucleus of the stria terminalis.” by Chloe Erikson, Gangze Wei and Brendan Walker
Presented by Yolanda Campos-Jurado, Phd student