Estradiol protects against pain-facilitated fentanyl use via suppression of opioid-evoked dopamine activity in males.
Jessica A. Higginbotham, Julian G. Abt, Rachel H. Teich, Joanna J. Dearman, Tania Lintz, Jose A. Morón.
Neuron. 2025 May 7.
Read Article
Peripheral opioid receptor antagonism alleviates fentanyl-induced cardiorespiratory depression and is devoid of aversive effects.
Brian C Ruyle, Sarah Masud, Rohith Kesaraju, Mubariz Tahirkheli, Juhi Modh, Caroline Roth, Sofia Angulo-Lopera, Tania Lintz, Jessica A Higginbotham, Nicolas Massaly, Jose A Moron.
eLife. 2024 Dec 10.
Read Article
An autonomous implantable device for the prevention of death from opioid overdose.
Ciatti JL, Vázquez-Guardado A, Brings VE, Park J, Ruyle B, Ober RA, McLuckie AJ, Talcott MR, Carter EA, Burrell AR, Sponenburg RA, Trueb J, Gupta P, Kim J, Avila R, Seong M, Slivicki RA, Kaplan MA, Villalpando-Hernandez B, Massaly N, Montana MC, Pet M, Huang Y, Morón JA, Gereau RW 4th, Rogers JA.
Sci Adv. 2024 Oct 25
Read Article
Peripheral opioid receptor antagonism alleviates fentanyl-induced cardiorespiratory depression and is devoid of aversive effects.
Ruyle BC, Masud S, Kesaraju R, Tahirkheli M, Modh J, Roth C, Angulo-Lopera S, Lintz T, Higginbotham JA, Massaly N, Moron JA.
bioRxiv [Preprint]. 2024 Oct 22
Read Article
Inflammatory pain in mice induces light cycle-dependent effects on sleep architecture.
Burek DJ, Ibrahim KM, Hall AG, Sharma A, Musiek ES, Morón JA, Carlezon WA.
bioRxiv [Preprint]. 2024 Aug 29
Read Article
Pannexin-1 channel inhibition alleviates opioid withdrawal in rodents by modulating locus coeruleus to spinal cord circuitry.
Kwok CHT, Harding EK, Burma NE, Markovic T, Massaly N, van den Hoogen NJ, Stokes-Heck S, Gambeta E, Komarek K, Yoon HJ, Navis KE, McAllister BB, Canet-Pons J, Fan C, Dalgarno R, Gorobets E, Papatzimas JW, Zhang Z, Kohro Y, Anderson CL, Thompson RJ, Derksen DJ, Morón JA, Zamponi GW, Trang T.
Nat Commun. 2024 Jul 24
Read Article
A locus coeruleus to dorsal hippocampus pathway mediates cue-induced reinstatement of opioid self-administration in male and female rats
Tamara Markovic, Jessica Higginbotham, Brian Ruyle, Nicolas Massaly, Hye Jean Yoon, Chao-Cheng Kuo, Jenny R. Kim, Jiwon Yi, Jeniffer J. Garcia, Eric Sze, Julian Abt, Rachel H. Teich, Joanna J. Dearman, Jordan G. McCall, Jose A. Morón
Neuropsychopharmalogy, In Press
Read Article
Dorsal hippocampus to nucleus accumbens projections drive reinforcement via activation of accumbal dynorphin neurons
Khairunisa Mohamad Ibrahim, Nicolas Massaly, Hye-Jean Yoon, Rossana Sandoval, Allie J. Widman, Robert J. Heuermann, Sidney Williams, WilliamPost, Sulan Pathiranage, Tania Lintz, Azra Zec, Ashley Park, Waylin Yu, Thomas L. Kash, Robert W. Gereau IV, & Jose A. Morón
Nature Communications, January 29, 2024
Read Article
Opioid research in the time of the opioid crisis
John R Traynor, Jose A Moron
British Journal of Pharmacology, February 22, 2023
Read Article
Inflammatory pain affects alcohol intake in a dose-dependent manner in male rats in the intermittent access model
Yolanda Campos-Jurado & Jose A. Morón
PAIN Reports, June 27, 2023
Read Article
Cnih3 Deletion Dysregulates Dorsal Hippocampal Transcription Across the Estrous Cycle
Bernard Mulvey, Hannah Frye, Tania Lintz, Stuart Fass, Eric Tycksen, Elliot Nelson, Jose Morón, and Joseph Dougherty
eNeuro, March 13, 2023
Read Article
Endogenous opioid systems alterations in pain and opioid use disorder
Jessica A. Higginbotham, Tamara Markovic, Nicolas Massaly and Jose A. Morón
Frontiers in Systems Neuroscience, 10/19/2022
Read Article
Time-dependent enhancement in ventral tegmental area dopamine neuron activity drives pain-facilitated fentanyl intake in males
Jessica A. Higginbotham, Julian G. Abt, Rachel H. Teich, Jose A. Moron
Preprint 8/22/2022
Read Article
Dorsal Hippocampus To Nucleus Accumbens Projections Drive Reinforcement Via Activation of Accumbal Dynorphin Neurons
Nicolas Massaly, Khairunisa Mohamad Ibrahim, Hye-Jean Yoon, Rossana Sandoval, Sidney Williams, Hannah Frye, William Post, Waylin Yu, Olayinka Idowu, Azra Zec, Sulan Pathiranage, Thomas Kash, Jose A. Moron
Preprint 8/10/2022
Read Article
Typical hippocampal transcriptional response across estrous is dysregulated by Cnih3 gene deletion
Bernard Mulvey, Hannah E. Frye, Tania Lintz, Stuart Fass, Eric Tycksen, Elliot C. Nelson, Jose A. Morón, Joseph D. Dougherty
Preprint 4/12/2022
Read Article
Pain induces adaptations in ventral tegmental area dopamine neurons to drive anhedonia-like behavior
Tamara Markovic, Christian E. Pedersen, Nicolas Massaly, Yvan M. Vachez, Brian Ruyle, Caitlin A. Murphy, Kavitha Abiraman, Jung Hoon Shin, Jeniffer J. Garcia, Hye Jean Yoon, Veronica A. Alvarez, Michael R. Bruchas, Meaghan C. Creed, Jose A. Morón
Nature Neuroscience, October 18, 2021
Read Article
An endogenous opioid circuit determines state-dependent reward consumption
Daniel C Castro, Corinna S Oswell, Eric T Zhang, Christian E Pedersen, Sean C Piantadosi, Mark A Rossi, Avery C Hunker, Anthony Guglin, Jose A Morón, Larry S Zweifel, Garret D Stuber, Michael R Bruchas
Nature, October 12, 2021
Read Article
Behavioral outcomes of complete Freund’s adjuvant-induced inflammatory pain in the rodent hind-paw: a systematic review and meta-analysis
Burek, Dominika; Massaly, Nicolas; Yoon, Hye Jean; Doering, Michelle; Morón, Jose
PAIN, August 27, 2021
Read Article
Sex Differences in the Role of Cornichon Homolog-3 on Spatial Memory and Synaptic Plasticity
Hannah E. Frye, Yukitoshi Izumi, Alexis N. Harris, Sidney B. Williams, Christopher R. Trousdale, Min-Yu Sun, Andrew D. Sauerbeck, Terrance T. Kummer, Steven Mennerick, Charles F. Zorumski, Elliot C. Nelson, Joseph D. Dougherty, Jose A. Morón
Biological Psychiatry, July 22, 2021
Read Article
Pain, negative affective states and opioid-based analgesics: Safer pain therapies to dampen addiction
Nicolas Massaly, PhD; Tamara Markovic, PhD; Meaghan Creed, PhD; Ream Al-Hasani, PhD; Catherine M Cahill, PhD; Jose A. Morón, PhD.
Int Rev Neurobiol, Feb 2nd 2021
Read Article
Effects of Inflammatory Pain on CB1 Receptor in the Midbrain Periaqueductal Gray
Adrianne Rae Wilson-Poe, PhD; Beth Wiese, PhD; Cherkaouia Kibaly, PhD; Lindsay Lueptow, PhD; Jeniffer Garcia, MS; Preeti Anand, MD; Catherine Cahill, PhD; Jose A. Morón, PhD.
PAIN Reports, Jan-Feb 2021
Read Article
Long-Term Inflammatory Pain Does Not Impact Exploratory Behavior and Stress Coping Strategies in Mice
Dominika J. Burek, B.A.; Nicolas Massaly, Ph.D.; Michelle Doering, B.A.; Azra Zec, B.S.; Jordan Gaelen, B.S.; Jose A Moron, PhD.
PAIN, Jan 5th 2021
Read Article
Dose-dependent induction of CPP or CPA by intra-pVTA ethanol: Role of mu opioid receptors and effects on NMDA receptors
Yolanda Campos-Juradoa, Lucía Martí-Prats, Jose A. Morón, Ana Polache, Luis Granero, Lucía Hipólito
Prog Neuropsychopharmacol Biol Psychiatry. June 8, 2020.
Read Article
Synthesis and Pharmacology of a Novel μ-δ Opioid Receptor Heteromer-Selective Agonist Based on the Carfentanyl Template
Abdelfattah Faouzi, Rajendra Uprety, Ivone Gomes, Nicolas Massaly, Attila I. Keresztes, Valerie Le Rouzic, Achla Gupta, Tiffany Zhang, Hye Jean Yoon, Michael Ansonoff, Abdullah Allaoa, Ying Xian Pan, John Pintar, Jose A. Morón, John M. Streicher, Lakshmi A. Devi, and Susruta Majumdar
J Med Chem. Nov 25, 2020.
Read Article
A Neurobehavioral Approach to Addiction: Implications for the Opioid Epidemic and the Psychology of Addiction.
Bechara A, Berridge DC, Bickel WK, Moron JA, Williams SB, Stein JS
Psychol Sci Public Interest. October 20, 2019.
Read Article
Cornichon Homolog-3 (CNIH3) Modulates Spatial Memory in Female Mice
Hannah E Frye, Sidney B Williams, Christopher R Trousdale, Elliot C Nelson, Joseph D Dougherty, and Jose A Moron.
BioRxiv. August 5, 2019.
Read Article
Pain-Induced Negative Affect Is Mediated via Recruitment of The Nucleus Accumbens Kappa Opioid System
Nicolas Massaly, Bryan A. Copits, Adrianne R. Wilson-Poe, Lucia Hipólito, Tamara Markovic, Hye Jean Yoon, Shiwei Liu, Marie C. Walicki, Dionnet L. Bhatti, Sunil Sirohi, Amanda Klaas, Brendan M. Walker, Rachael Neve, Catherine M. Cahill, Kooresh I. Shoghi, Robert W. Gereau, Jordan G. McCall, Ream Al-Hasani, Michael R. Bruchas, Jose A. Morón
Neuron. March 13, 2019
Read Article
Hippocampal Activity Dynamics During Contextual Reward Association in Virtual Reality Place Conditioning.
Sidney B Williams, Moises Arriaga, William W Post, Akshata A Korgaonkar, Jose A Moron, Edward B. Han
BioRxiv. February 10, 2019.
Read Article
Opioid receptors inhibit the spinal AMPA receptor Ca2+ permeability that mediates latent pain sensitization.
Taylor BK, Sinha GP, Donahue RR, Grachen CM, Morón JA, Doolen S
Experimental Neurology. 2019 Apr; 314:58-66.
Read Article
Pain And Opioid Systems, Implications In The Opioid Epidemic.
Nicolas Massaly, Jose A Morón
Current Opinion in Behavioral Sciences Volume 26, April 2019, Pages 69-74
Read Article
Rescue of Learning and Memory Deficits in the Human Nonsyndromic Intellectual Disability Cereblon Knock-Out Mouse Model by Targeting the AMP-Activated Protein Kinase-mTORC1 Translational Pathway.
Bavley CC, Rice RC, Fischer DK, Fakira AK, Byrne M, Kosovsky M, Rizzo BK, Del Prete D, Alaedini A, Morón JA, Higgins JJ, D’Adamio L, Rajadhyaksha AM
Journal of Neuroscience. 2018 Mar 14;38(11):2780-2795.
Read Article
The dynamic interaction between pain and opioid misuse.
Wilson-Poe AR, Morón JA
British Journal of Pharmacology. 2018 Jul;175(14):2770-2777.
Read Article
Identification of an epidermal keratinocyte AMPA glutamate receptor involved in dermatopathies associated with sensory abnormalities.
Cabañero D, Irie T, Celorrio M, Trousdale C, Owens DM, Virley D, Albrecht PJ, Caterina MJ, Rice FL, Morón JA
PAIN Reports. 2016 Sep;1(3). pii: e573.
Read Article
A Trigger for Opioid Misuse: Chronic Pain and Stress Dysregulate the Mesolimbic Pathway and Kappa Opioid System.
Massaly N, Morón JA, Al-Hasani R
Frontiers in Neuroscience. 2016 Nov 7;10:480
Read Article
Identification of an epidermal keratinocyte AMPA glutamate receptor involved in dermatopathies associated with sensory abnormalities.
Cabanero D, Irie T, Celorrio M, Trousdale C, Owens DM, Virley D, Albrecht PH, Caterina MJ, Rice FL, Moron JA
PAIN Reports. September 2016, Volume 1, Issue 3, p. e573.
Read Article
Morphine-Associated Contextual Cues Induce Structural Plasticity in Hippocampal CA1 Pyramidal Neurons.
Fakira AK, Massaly N, Cohensedgh O, Berman A, Morón JA
Neuropsychopharmacology. 2016 Oct;41(11):2668-78.
Read Article
Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia.
Moreno JL, Miranda-Azpiazu P, García-Bea A, Younkin J, Cui M, Kozlenkov A, Ben-Ezra A, Voloudakis G, Fakira AK, Baki L, Ge Y, Georgakopoulos A, Morón JA, Milligan G, López-Giménez JF, Robakis NK, Logothetis DE, Meana JJ, González-Maeso J
Science Signaling. 2016 Jan 12;9(410):ra5.
Read Article
Inflammatory Pain Promotes Increased Opioid Self-Administration: Role of Dysregulated Ventral Tegmental Area μ Opioid Receptors.
Hipólito L, Wilson-Poe A, Campos-Jurado Y, Zhong E, Gonzalez-Romero J, Virag L, Whittington R, Comer SD, Carlton SM, Walker BM, Bruchas MR, Morón JA
The Journal of Neuroscience. 2015 Sep 2;35(35):12217-31.
Read Article
Evidence of CNIH3 involvement in opioid dependence.
Nelson EC, Agrawal A, Heath AC, Bogdan R, Sherva R, Zhang B, Al-Hasani R, Bruchas MR, Chou YL, Demers CH.,Carey CE, Conley ED, Fakira AK, Farrer LA, Goate A, Gordon S, Henders AK, Hesselbrock V, Kapoor M, Lynskey MT, Madden PA, Moron JA, Rice JP, Saccone NL, Schwab SG, Shand FL, Todorov AA, Wallace L, Wang T, Wray NR, Zhou X, Degenhardt L, Martin NG, Hariri AR, Kranzler HR, Gelernter J, Bierut LJ, Clark DJ, Montgomery GW
Molecular Psychiatry. 2016 May;21(5):608-14.
Read Article
Upregulation of dopamine D2 receptors in the nucleus accumbens indirect pathway increases locomotion but does not reduce alcohol consumption.
Gallo EF, Salling MC, Feng B, Morón JA, Harrison NL, Javitch JA, Kellendonk C
Neuropsychopharmacology. 2015 Jun;40(7):1609-18.
Read Article
In vivo activation of the SK channel in the spinal cord reduces the NMDA receptor antagonist dose needed to produce antinociception in an inflammatory pain model.
Hipólito L, Fakira AK, Cabañero D, Blandón R, Carlton SM, Morón JA, Melyan Z
PAIN. 2015 May;156(5):849-58.
Read Article
Implication of delta opioid receptor subtype 2 but not delta opioid receptor subtype 1 in the development of morphine analgesic tolerance in a rat model of chronic inflammatory pain.
Beaudry H, Gendron L, Morón JA
European Journal of Neuroscience. 2015 Apr;41(7):901-7.
Read Article
Increased small conductance calcium-activated potassium type 2 channel-mediated negative feedback on N-methyl-D-aspartate receptors impairs synaptic plasticity following context-dependent sensitization to morphine.
Fakira AK, Portugal GS, Carusillo B, Melyan Z, Morón JA
Biological psychiatry. 2014 Jan 15;75(2):105-14.
Read Article
Hippocampal long-term potentiation is disrupted during expression and extinction but is restored after reinstatement of morphine place preference.
Portugal GS, Al-Hasani R, Fakira AK, Gonzalez-Romero JL, Melyan Z, McCall JG, Bruchas MR, Morón JA
The Journal of Neuroscience. 2014 Jan 8;34(2):527-38.
Read Article
Systemic morphine treatment induces changes in firing patterns and responses of nociceptive afferent fibers in mouse glabrous skin.
Hogan D, Baker AL, Morón JA, Carlton SM (2013)
PAIN, 154(11):2297-309.
Read Article
Pain after discontinuation of morphine treatment is associated with synaptic increase of GluA4-containing AMPAR in the dorsal horn of the spinal cord.
Cabañero D, Baker A, Zhou S, Hargett GL, Irie T, Xia Y, Beaudry H, Gendron L, Melyan Z, Carlton SM (2013)
Neuropsychopharmacology, 38(8):1472-84.
Read Article
Hippocampal GluA1-containing AMPA receptors mediate context-dependent sensitization to morphine.
Xia Y, Portugal GS, Fakira AK, Melyan Z, Neve R, Lee HT, Russo SJ, Liu J, Morón JA (2011)
The Journal of Neuroscience, 31(45):16279-91.
Read Article
Disruption of morphine-conditioned place preference by a delta2-opioid receptor antagonist: study of mu-opioid and delta-opioid receptor expression at the synapse.
Billa SK, Xia Y, Morón JA (2010)
The European Journal of Neuroscience, 32(4):625-31.
Read Article
Increased insertion of glutamate receptor 2-lacking alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors at hippocampal synapses upon repeated morphine administration.
Billa SK, Liu J, Bjorklund NL, Sinha N, Fu Y, Shinnick-Gallagher P, Morón JA (2010)
Molecular Pharmacology, 77(5):874-83.
Read Article
Extinction of morphine-dependent conditioned behavior is associated with increased phosphorylation of the GluR1 subunit of AMPA receptors at hippocampal synapses.
Billa SK, Sinha N, Rudrabhatla SR, Morón JA (2009)
The European Journal of Neuroscience, 29(1):55-64.
Read Article